[Frustrated Phagocytosis Logo] Science of the Health Effects of Fibers

Definitions


 

Biosoluble means fibers meet one of the following criteria:

  1. No irreversible lung disease in state of the art lifetime rat chronic inhalation study.
  2. Long fibers clear from lungs as fast or faster than fibers that meet criteria 1.
  3. kdis of 100 ng/cm2/hr or more as measured by OC standard technique. (a)
  4. The fiber has a composition for which kdis may be calculate accurately by accepted methods and the kdis is 100 ng/cm2/hr or greater. (b,c,d)

 
  1. A mathematical model of fiber carcinogenicity and fibrosis in inhalation and intraperitoneal experiments in rats by W. Eastes and J. G. Hadley. Originally published in 1996 by Inhalation Toxicology 8, 323-343.
    Read the paper or Download it (57 kB).
     
  2. Estimating rock and slag wool fiber dissolution rate from composition by W. Eastes, R. M. Potter, and J. G. Hadley. Originally published in 2000 by Inhalation Toxicology 12, 1127-1139.
    Read the paper or Download it (24 kB).
     
  3. Estimation of dissolution rate from in-vivo studies of synthetic vitreous fibers by W. Eastes, R. M. Potter, and J. G. Hadley. Originally published in 2000 by Inhalation Toxicology 12, 1037-1054.
    Read the paper or Download it (31 kB).
     
  4. Estimating in-vitro glass fiber dissolution rate from composition by W. Eastes, R. M. Potter, and J. G. Hadley. Originally published in 2000 by Inhalation Toxicology 12, 269-280.
    Read the paper or Download it (23 kB).
     

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